Andarine (S4):
What You Should Know
What is Andarine?
Andarine (S4) is a Selective Androgen Receptor Modulator (SARM) that was originally developed to treat muscle and bone wasting. It is often used by bodybuilders and athletes to maintain muscle mass and reduce fat.
As a SARM, Andarine acts more selectively than conventional anabolic steroids because it preferentially binds to androgen receptors in muscle and bone tissue. This results in fewer side effects compared to other anabolic substances.
Benefits of Andarine
- Increased muscle mass: Andarine binds to the androgen receptor, stimulating muscle protein synthesis and promoting lean muscle growth.
- Increased strength: Users often report significant improvements in strength and endurance, making it beneficial for athletic performance.
- Fat loss: By enhancing metabolic activity, Andarine supports fat oxidation, leading to a leaner physique.
- Improved bone density: Studies suggest that Andarine can strengthen bones by increasing mineral density, reducing the risk of fractures.
Andarine mechanism of action
Andarine (S4) belongs to the class of selective androgen receptor modulators (SARMs) and binds to androgen receptors. This binding activates anabolic processes that promote muscle growth, increase strength, and support fat loss.
Similar to testosterone, Andarine exerts its effects by activating androgen receptors. However, it targets specifically muscle and bone tissue, which means typical side effects such as enlarged prostate or hair loss occur less frequently.
A particular advantage of Andarine is its positive effect on bone density. It was originally developed to treat osteoporosis, as it inhibits bone degradation and contributes to skeletal stability. Additionally, Andarine is characterized by a pronounced fat-burning effect, making it particularly attractive during diet phases.
Side Effects of Andarine
Mild, common side effects:
- Headaches
- Mood swings
Severe, rare side effects:
- Vision problems
- Mild hormonal suppression
- Liver toxicity
Does Andarine Affect Vision?
Yes, Andarine (S4) can temporarily impair vision in some users. This side effect usually occurs at higher dosages (e.g., 75 mg).
Users frequently report:
- Yellowish tint in the visual field (especially at night)
- Limited night vision
- Light sensitivity
Why does Andarine impair vision?
Andarine is an androgenic substance that binds to androgen receptors in the body. These receptors are found not only in muscles and bones but also in the retina of the eye.
Unlike other SARMs such as Ostarine or RAD-140, Andarine has a particular affinity for these receptors in the eye. This can lead to temporary changes in color perception and light adaptation.
Are the vision problems permanent?
Vision problems caused by Andarine (S4) are generally temporary. Once you stop taking the SARM, they usually disappear within a few days to weeks.
Does Andarine Suppress Testosterone?
Yes, like other SARMs, Andarine can suppress testosterone production.
The good news: Andarine is among the SARMs with the least suppression and affects testosterone levels significantly less than stronger SARMs like RAD-140 or LGD-4033.
Why do SARMs suppress testosterone?
The body regulates testosterone production through the hypothalamic-pituitary-testicular axis (HPTA). When SARMs bind to androgen receptors, it signals to the brain that enough androgens are present. [R]
This inhibits the release of LH (Luteinizing Hormone) and FSH (Follicle-Stimulating Hormone). Since LH and FSH are crucial for natural testosterone production, their inhibition leads to reduced testosterone production.
How to store Andarine
Andarine is available in both liquid and solid forms. Regardless of the form, it should be stored under the following conditions:
- Keep Andarine at room temperature between 15°C and 30°C (59°F to 86°F)
- Store it in a dark place, away from direct light exposure
- Avoid significant temperature fluctuations
- Freezing is possible but not recommended
Frequently Asked Questions
What is the half-life of Andarine?
The half-life of Andarine is very short, approximately 4 hours [R]. However, anecdotal reports suggest that it may be higher.
What other names is Andarine known by?
Other names for Andarine include:
- S-4
- GTx-007 (developed by GTx Inc.)
- Acetamidoxolutamide (chemical name)
Is Andarine S4 better for cutting or bulking?
Andarine (S4) is primarily used for cutting, as it helps with fat loss while preserving lean muscle mass. While it can be used during a bulk, it's not the best choice for building muscle, as its anabolic effects are weaker compared to other compounds. However, it does support strength and muscle hardness, even in a calorie deficit.
How long is Andarine detectable?
In a study, Andarine was still detectable in urine up to 2 weeks after taking a single dose of 60 mg [R].
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